Intermittent Hypoxia Impairs Glucose Homeostasis in C57BL6/J Mice: Partial Improvement with Cessation of the Exposure
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چکیده
منابع مشابه
Altered Metabolic Responses to Intermittent Hypoxia in Mice with Partial Deficiency of Hypoxia-inducible Factor
We have previously shown that exposure of C57BL/6J mice to intermittent hypoxia (IH) leads to: (1) hypertriglyceridemia due to up-regulation of pathways of lipid biosynthesis, including sterol regulatory element binding protein 1 (SREBP-1) and stearoyl CoA desaturase 1 (SCD-1); and (2) hypercholesterolemia due to impaired cholesterol uptake. The goal of the present study was to examine whether ...
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We have previously shown that exposure of C57BL/6J mice to intermittent hypoxia (IH) leads to 1) hypertriglyceridemia due to upregulation of pathways of lipid biosynthesis, including sterol regulatory element binding protein (SREBP)-1 and stearoyl CoA desaturase (SCD)-1; and 2) hypercholesterolemia due to impaired cholesterol uptake. The goal of the present study was to examine whether hypoxia-...
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Defective insulin secretion in response to glucose is an important component of the beta cell dysfunction seen in type 2 diabetes. As mitochondrial oxidative phosphorylation plays a key role in glucose-stimulated insulin secretion (GSIS), oxygen-sensing pathways may modulate insulin release. The von Hippel-Lindau (VHL) protein controls the degradation of hypoxia-inducible factor (HIF) to coordi...
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We previously reported the unexpected finding that 4 wk of exposure to intermittent hypoxia (IH), which simulates the hypoxic stress of obstructive sleep apnea, improved LV cardiac function in healthy, lean C57BL/6J mice. The purpose of the present study was to assess the impact of 4 wk of IH on cardiac function in a transgenic murine model that exhibits a natural history of heart failure. We h...
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ژورنال
عنوان ژورنال: Sleep
سال: 2013
ISSN: 0161-8105,1550-9109
DOI: 10.5665/sleep.3040